London: A stressful job could make you old and sick before time, as a new study suggests that people with high stress work tend to have shorter telomeres, which has been associated with several diseases.Telomeres, located at the ends of chromosomes, serve as a type of protective cap to the ropy strands and their shortening has been linked to Parkinson's disease, type 2 diabetes, cardiovascular disease and cancer.
The research led by Kirsi Ahola of the Finnish Institute of Occupational Health measured the length of DNA sections called telomeres and how the lengths varied in association with job stress.
The study found that people suffering from the most job stress tended to have shorter telomeres. Telomeres assure that the genetic instructions carried by genes on the chromosomes are accurately translated so cells get the right messages. They shorten with age, oxidation and chemical insults.
Often, when telomeres reach a critically short length, the cell dies in a process called apoptosis, according to NBC News.
Some cells do not die, but rather become what scientists call 'senescent' — they start making genetic errors and causing damage.
Ahola and her team analyzed blood cells called leukocytes, which are critical to immune function, in 2,911 people between ages 30 and 64.
They found that workers who experienced severe exhaustion from job stress had significantly shorter leukocyte telomeres than their relatively stress-free counterparts. PTI