A genetic way to live 125 years

Imagine living to a healthy 125 years. Well, your imagination might someday turn into reality, thanks to scientists who have made a genetic breakthrough that they claim can prolong human life and remove cancer threat.

A team at the Spanish National Cancer Research Centre in Madrid has based its conclusion on tests on rodents, which made them live nearly 45 per cent longer and also left them free from tumours.

According to the scientists, if the experiments on the mice can be replicated in people, human lifespan could also be extended as the genes involved exist naturally in both rodents and humans and perform similar roles.

"The elixir of eternal youth is now not a utopian dream. The discovery opens the door to (the possibility) that humans could live 125 years and without cancer," the Daily Mail quoted lead scientist Maria Blasco as saying.

In fact, the scientists achieved their results by inserting an extra copy of three genes—called telomerase, p53 and p16, already known to be important for longevity and suppressing tumours— into the stem cells of mice.

Inserting an extra copy improved their function in the body because they produced more protein, which made them more active.

This in turn helped telomerase to protect chromosomes from shrinking, a process which normally happens naturally as all living creatures age.

And it means p53 and p16 work to prevent cells from mutating and dividing, and therefore preventing cancer, while producing a good balance of new, healthy cells—the method is "groundbreaking" as the team managed to get extra copies of both the genes into the mice.

The modified mice were allowed to breed to strengthen their new DNA pattern, which created a group of "supermice" with longer lifespans and in-built cancer protection.

"When activating p53 and p16 in mice, the incidence of cancer is reduced to practically zero. We don't think the mice lived longer because they had less cancer but because these genes also protected against ageing," co-scientist Manuel Serrano said. The mice are expected to live up to four-and-a-half years though normally their average lifespan is three years. "This is the equivalent of humans living to 125," according to the scientists.